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COMPLEX, PROTEASOME ENDOPEPTIDASE
Descriptors Found:
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DeCS
Descriptor
English
:
Proteasome Endopeptidase Complex
Descriptor
Spanish
:
Complejo de la Endopetidasa Proteasomal
Descriptor
Portuguese
:
Complexo de Endopeptidases do Proteassoma
Synonyms
English
:
20S Proteasome
Ingensin
Macropain
Macroxyproteinase
Multicatalytic Endopeptidase Complex
Multicatalytic Proteinase
Prosome
Proteasome
Complex, Multicatalytic Endopeptidase
Complex, Proteasome Endopeptidase
Endopeptidase Complex, Multicatalytic
Endopeptidase Complex, Proteasome
Proteasome, 20S
Proteinase, Multicatalytic
Tree Number:
D05.500.562.500
D08.811.277.656.918
D08.811.600.730
Definition
English
:
A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and
nuclear proteins
in
eukaryotic cells
. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests
ubiquitinated proteins
and protein activated via
ornithine decarboxylase
antizyme.
Entry Combination - descr/qualif
English
:
Proteasome Endopeptidase Complex
/
antagonists & inhibitors
use
Proteasome Inhibitors
See Related
English
:
Ubiquitin-Protein Ligase Complexes
History Note
English
:
2005; use PROTEASOME ENDOPEPTIDASE COMPLEX (NM) 1986-2004
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
38685
Unique Identifier:
D046988
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS